Fast dissolving drug delivery system offer a solution for those patients having difficulty in swallowing tablet or capsule etc. Diclofenac Sodium, a non steroidal anti-inflammatory drug with analgesic and anti-inflammatory property was selected as the model drug. The present study investigated to development of novel fast dissolving oral films of Diclofenac Sodium which was by pass first pass metabolism, provide rapid onset of action and increasing the bioavailability of the drug. The fast dissolving films were prepared by solvent casting method by using HPMC K100M as film forming polymer, due to their hydrophilic nature and palatable taste. All the film formulations (F1-F3) were evaluated for their weight variations, thickness, surface pH, folding endurance, tensile strength, percentage elongation, in-vitro disintegration, drug content and in-vitro drug release studies.
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